تفاعل #167247

معادلة التفاعل

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

2-bromo-5-chloro-thiophene

trans-1,2-diamino cyclohexane

potassium carbonate

→

product

المردود 48.4%

1-(5-Chloro-thiophen-2-yl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

المردود 48.4%

المذيبات

1,4-dioxane

ظروف التفاعل

المعالجة

1. 1
   أخرىto afford the crude product
2. 2
   أخرىPurification by column chromatography on silica gel (1% MeOH in DCM)

الإجراء التجريبي

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 300 mg, 1.6949 mmol) was reacted with 2-bromo-5-chloro-thiophene (0.185 mL, 1.6949 mmol), 1,4-dioxane (10 mL), copper iodide (32 mg, 0.169 mmol), trans-1,2-diamino cyclohexane (58 mg, 0.5084 mmol) and potassium carbonate (467 mg, 3.3898 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% MeOH in DCM) afforded 240 mg of the product (48.4% yield).

المصدر