تفاعل #1671306

معادلة التفاعل

2-(4-methylthiophenyl)aniline

dibromopentane

2-bromoaniline

2-bromoaniline

→

1-[2-(4-methylthiophenyl)phenyl]piperidine

المذيبات

triethylamine

ظروف التفاعل

الإجراء التجريبي

Compounds of Formula I wherein X is a single bond and R1 is 1-piperidinyl or I-pyrrolyl can be prepared from 2-bromoaniline as shown in Scheme 15. Suzuki coupling of 2-bromoaniline with 4-thiomethylphenylboronic acid using the method described above followed by condensation of the resulting 2-(4-methylthiophenyl)aniline with dibromopentane in the presence of an amine base, such as triethylamine, affords the corresponding 1-[2-(4-methylthiophenyl)phenyl]piperidine. Oxidation if the methylthio to the methylsulfonyl using methods described above provides compounds of Formula I wherein R1 is 1-piperidinyl. Alternately the starting 2-bromoaniline can be converted to the 1-[(2-bromophenyl)phenyl]pyrrole by treatment with 2,5-dimethoxytetrahydrofuran in glacial acetic acid. Suzuki coupling of the resulting intermediate with 4-methylthiophenylboronic acid followed by oxidation, as described above, gives the 1-[2-(4-methylsulfonylphenyl)phenyl]pyrrole. ##STR26##

المصدر