تفاعل #1668670

معادلة التفاعل

3-(3-chloro-benzenesulfonyl)-6-methoxy-pyridazine

hydrochloric acid

→

6-(3-chloro-benzenesulfonyl)-2H-pyridazin-3-one

المردود 43.4%

المذيبات

dioxane

ظروف التفاعل

المعالجة

1. 1
   أخرىwas prepared
2. 2
   درجة الحرارةrefluxed for 30 minutes
3. 3
   أخرىThe reaction mixture was then evaporated to dryness
4. 4
   استخلاصthe residue was extracted with ethyl acetate (2×10 mL)
5. 5
   أخرىThe ethyl acetate mixture was collected
6. 6
   تجفيفdried over anhydrous sodium sulfate
7. 7
   ترشيحfiltered
8. 8
   أخرىthe filtrate was evaporated to dryness

الإجراء التجريبي

A mixture of 3-(3-chloro-benzenesulfonyl)-6-methoxy-pyridazine (148 mg), dioxane (2 mL) and concentrated hydrochloric acid (0.5 mL) was prepared and refluxed for 30 minutes. The reaction mixture was then evaporated to dryness and the residue was extracted with ethyl acetate (2×10 mL). The ethyl acetate mixture was collected, dried over anhydrous sodium sulfate, filtered and the filtrate was evaporated to dryness to afford 6-(3-chloro-benzenesulfonyl)-2H-pyridazin-3-one as white solid (38%, 61 mg); mp, 222-223° C.: NMR, 7.11 (d, 1H), 7.74 (t, 1H), 7.86-8.04 (m, 4H), 13.86 (s, 1H).

المصدر