تفاعل #1667987

معادلة التفاعل

hydrogen

2-bromo-4,5-diphenyl-oxazole

thioglycolic acid ethyl ester

2-chloro-4,5-diphenyl-oxazole

NaH

→

4,5-diphenyl-2-oxazolyl-mercaptoacetic acid

المذيبات

DMF

ظروف التفاعل

الإجراء التجريبي

12 g. of thioglycolic acid ethyl ester is added to a suspension of 2.4 g. of NaH in 200 ml. of freshly distilled DMF, and the mixture is agitated until the evolution of hydrogen has ceased. Thereafter, 25.5 g. of 2-chloro-4,5-diphenyl-oxazole or 30 g. of 2-bromo-4,5-diphenyl-oxazole is added to the mixture. The latter is agitated for 5 hours at 80° and worked up as usual, thus obtaining the ethyl ester of 4,5-diphenyl-2-oxazolyl-mercaptoacetic acid, b.p. 207°-210°/0.1 mm.; m.p. 54°-56° (hexane).

المصدر