تفاعل #166652

معادلة التفاعل

2-(chloromethyl)-4-methylthiazole hydrochloride

3-iodo-4-nitro-1H-indazole

potassium carbonate

→

2-((3-iodo-4-nitro-1H-indazol-1-yl)methyl)-4-methylthiazole

المردود 60.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated under reduced pressure
2. 2
   workup.ADDITIONdiluted with DCM and brine
3. 3
   أخرىThe organic phase was dried
4. 4
   workup.ADDITION(phase separator silicone treated filter paper)
5. 5
   أخرىpurified by silica gel chromatography (10-50% ether in DCM)

الإجراء التجريبي

To a solution of 3-iodo-4-nitro-1H-indazole (0.500 g, 1.73 mmol) in DMF (8 mL) was added potassium carbonate (0.478 g, 3.46 mmol) at ambient temperature. After 15 minutes, 2-(chloromethyl)-4-methylthiazole hydrochloride was added. The mixture was allowed to stir at ambient temperature for 18 hours, concentrated under reduced pressure and diluted with DCM and brine. The organic phase was dried (phase separator silicone treated filter paper), and purified by silica gel chromatography (10-50% ether in DCM) to provide 2-((3-iodo-4-nitro-1H-indazol-1-yl)methyl)-4-methylthiazole (0.414 g, 60% yield) as a yellow solid.

المصدر