تفاعل #166413

معادلة التفاعل

lithium aluminum hydride

compound 399

9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one

→

compound 402

المردود 82.7%

9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecane

المردود 82.7%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter 1.25 hours of reflux the reaction
2. 2
   أخرىquenched with water (2.22 mL)
3. 3
   ترشيحThe remaining solids were filtered off
4. 4
   تركيزthe filtrate was concentrated

الإجراء التجريبي

To a stirring mixture of lithium aluminum hydride (2.22 g, 58.5 mmol) in tetrahydrofuran (70 mL) was added compound 399 (3.60 g, 13.8 mmol), portionwise over three minutes. After 1.25 hours of reflux the reaction was cooled to room temperature and quenched with water (2.22 mL), then 1N NaOH (2.22 mL), then water (2×2.22 mL). The remaining solids were filtered off, and the filtrate was concentrated to give compound 402 (2.81 g, 82%). LCMS-ESI (POS), M/Z, M+1: Found 247.1, Calculated 247.2.

المصدر