تفاعل #166101
ord-28789426881a467095cbe816b9279bf3
معادلة التفاعل
(2S)-2-benzhydryl-oxirane
vinylmagnesium bromide
CuI
(2S)-1,1-diphenyl-pent-4-ene-2-ol
→
(2R)-1,1-diphenyl-pent-4-ene-2-ol
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
الإجراء التجريبي
(2S)-2-benzhydryl-oxirane (0.61 g, 2.91 mmol) was reacted with vinylmagnesium bromide (7.26 ml of 1.0M solution in THF, 7.26 mmol) in the presence of CuI (0.055 g, 0.29 mmol) (Procedure A) to yield (2R)-1,1-diphenyl-pent-4-ene-2-ol 0.48 g (70%, [α]D=(+)26, c=1, MeOH). The 1HNMR and 13CNMR were identical with (2S)-1,1-diphenyl-pent-4-ene-2-ol.