تفاعل #165929

معادلة التفاعل

Ethyl-2-(3-bromo-2-methoxytetrahydrofuran-3-yl)-2-oxoacetate

Triethyl amine

Hydrogen

→

Ethyl-2-(2-methoxytetrahydrofuran-3-yl)-2-oxoacetate

المردود 98.1%

المذيبات

Ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىreaction
2. 2
   أخرىReaction mass
3. 3
   ترشيحwas filtered through hyflow
4. 4
   تركيزconcentrated to residue
5. 5
   ترشيحfiltered
6. 6
   أخرىto remove triethylamine HBr salt
7. 7
   تركيزFiltrate was concentrated

الإجراء التجريبي

Ethyl-2-(3-bromo-2-methoxytetrahydrofuran-3-yl)-2-oxoacetate (8.5 g) was dissolved in Ethanol (85 ml). Triethyl amine (3.66 g) was added to the reaction mass. 5% Palladium on Carbon (0.85 g) was added and reaction was hydrogenated at 4-5 kg pressure of Hydrogen for 8 hrs. Reaction mass was filtered through hyflow and concentrated to residue. This residue was slurried in methyltert-butylether (42 ml) and filtered to remove triethylamine HBr salt. Filtrate was concentrated to get oily residue of Ethyl-2-(2-methoxytetrahydrofuran-3-yl)-2-oxoacetate (yield 6.0 g).

المصدر