تفاعل #165928

معادلة التفاعل

Ethyl-2-(4,5-dihydrofuran-3-yl)-2-oxoacetate

Ethanol

N-bromosuccinimide

→

Ethyl-2-(3-bromo-2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىreaction mass
2. 2
   درجة الحرارةby maintaining temp below 10° C
3. 3
   أخرىReaction mass
4. 4
   أخرىReaction mass
5. 5
   غسيلwas washed with sodium bicarbonate solution (8%, 3×400 ml)
6. 6
   أخرىReaction mass
7. 7
   تركيزwas then concentrated to residue

الإجراء التجريبي

Ethyl-2-(4,5-dihydrofuran-3-yl)-2-oxoacetate (100 g) was dissolved in dichloromethane (500 ml) and Ethanol (150 ml) was added to reaction mass and then reaction mass was cooled to 5 to 10° C. N-bromosuccinimide (115 g) was added lot wise by maintaining temp below 10° C. Reaction mass was then stirred at 20-30° C. till completion of reaction. Reaction mass was washed with sodium bicarbonate solution (8%, 3×400 ml). Reaction mass was then concentrated to residue to get Ethyl-2-(3-bromo-2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate (Yield 170 g).

المصدر