تفاعل #165779

معادلة التفاعل

NaHCO3

3-amino-N′-(benzoyloxy)-6-bromopyrazine-2-carboximidamide

→

5-bromo-3-(5-phenyl-1,2,4-oxadiazol-3-yl)pyrazin-2-amine

المردود 76.0%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةto cool to RT
2. 2
   أخرىThe resulting precipitate was isolated by filtration
3. 3
   أخرىdried (643 mg, 76% Yield)

الإجراء التجريبي

3-amino-N′-(benzoyloxy)-6-bromopyrazine-2-carboximidamide (890 mg, 2.648 mmol) and polyphosphonic acid (3.560 mL) were mixed and the reaction heated to 70° C. Further polyphosphonic acid (8.900 mL) was added and the reaction allowed to stir for a further 3 hours at 70° C. The mixture was then allowed to cool to RT, diluted with water and neutralised by the portionwise addition of solid NaHCO3. The resulting precipitate was isolated by filtration and dried (643 mg, 76% Yield). 1H NMR (400.0 MHz, DMSO) d 7.49 (2H, br s), 7.69 (2H, m), 7.77 (1H, m), 8.28 (2H, m), 8.43 (1H, s); MS (ES+) 319.89

المصدر