تفاعل #165751

معادلة التفاعل

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide

triethylamine

benzoyl chloride

→

product

المردود 70.0%

3-amino-N′-(benzoyloxy)-6-bromopyrazine-2-carboximidamide

المردود 70.0%

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwere added
2. 2
   أخرىthe solvent was removed in vacuo
3. 3
   أخرىthe residue triturated with MeOH
4. 4
   ترشيحThe resultant filtrate was filtered off

الإجراء التجريبي

3-amino-6-bromo-N′-hydroxypyrazine-2-carboximidamide (770 mg, 3.318 mmol) was suspended in DCM (10 mL) and triethylamine (369.3 mg, 508.7 μL, 3.650 mmol) followed by benzoyl chloride (513.1 mg, 423.7 μL, 3.650 mmol) were added. After 1 hour, the solvent was removed in vacuo and the residue triturated with MeOH. The resultant filtrate was filtered off to furnish the product as an off-white solid (779 mg, 70% Yield).

المصدر