تفاعل #165260

معادلة التفاعل

2-Chloromethyl-5-fluoro-pyridine

N,N-dimethylformamide

2-fluoro-4-hydroxy-benzaldehyde

sodium hydride

→

title compound

المردود 42.2%

2-Fluoro-4-(5-fluoro-pyridin-2-ylmethoxy)-benzaldehyde

المردود 42.2%

المذيبات

Water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas then added at room temperature
2. 2
   workup.STIRRINGstirred for 30 minutes at 80° C
3. 3
   استخلاصwas then extracted with ethyl acetate
4. 4
   غسيلThe organic layer was washed with saturated aqueous sodium chloride
5. 5
   أخرىthe solvent was evaporated under a reduced pressure
6. 6
   أخرىThe residue was purified by silica gel column chromatography (ethyl acetate: heptane=1:5→1:2)

الإجراء التجريبي

To an N,N-dimethylformamide (20.0 mL) solution of 2-fluoro-4-hydroxy-benzaldehyde (1.48 g, 10.2 mmol) was added sodium hydride (411 mg, 10.3 mmol, 60% in oil) under nitrogen atmosphere at 0° C., which was stirred for 20 minutes at room temperature. 2-Chloromethyl-5-fluoro-pyridine (1.20 g, 8.56 mmol) described in Manufacturing Example 41-1-2 was then added at room temperature, and stirred for 30 minutes at 80° C. Water was added at room temperature to the reaction solution, which was then extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride, and the solvent was evaporated under a reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate: heptane=1:5→1:2) to obtain the title compound (901 mg, 42.2%).

المصدر