تفاعل #165056

معادلة التفاعل

(3-phenoxy-phenyl)-methanol

triphenylphosphine

carbon tetrachloride

→

title compound

المردود 94.0%

1-Chloromethyl-3-phenoxy-benzene

المردود 94.0%

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المعالجة

1. 1
   درجة الحرارةunder reflux
2. 2
   تركيزconcentrated under a reduced pressure
3. 3
   أخرىThe residue was purified by silica gel column chromatography (heptane:ethyl acetate=10:1)

الإجراء التجريبي

To a solution of (3-phenoxy-phenyl)-methanol (2.00 g, 10.0 mmol) in carbon tetrachloride (40 mL) was added triphenylphosphine (3.15 g, 12.0 mmol) at room temperature. The reaction solution was stirred under nitrogen atmosphere for 5 hours and 40 minutes under reflux. The reaction mixture was cooled to room temperature and concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=10:1) to obtain the title compound (2.05 g, 94%).

المصدر