تفاعل #165038

معادلة التفاعل

2-amino-3-formylpyridine

hydroxylamine hydrochloride

→

title compound

المردود 85.0%

2-Amino-pyridine-3-carbaldehyde oxime

المردود 85.0%

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction solution was partitioned into water and ethyl acetate
2. 2
   غسيلThe organic layer was washed with water and saturated aqueous sodium chloride
3. 3
   تجفيفdried over anhydrous magnesium sulfate
4. 4
   أخرىthe solvent was evaporated under a reduced pressure
5. 5
   أخرىThe residue was purified by NH silica gel column chromatography (ethyl acetate: methanol=10:1)

الإجراء التجريبي

To a solution of 2-amino-3-formylpyridine (1.00 g, 8.19 mmol) in pyridine (20 mL) was added hydroxylamine hydrochloride (854 mg, 12.3 mmol) at room temperature, which was stirred for 1 hour and 40 minutes at room temperature. The reaction solution was partitioned into water and ethyl acetate. The organic layer was washed with water and saturated aqueous sodium chloride, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under a reduced pressure. The residue was purified by NH silica gel column chromatography (ethyl acetate: methanol=10:1) to obtain the title compound (951 mg, 85%).

المصدر