تفاعل #164884

معادلة التفاعل

3-fluoro-N-(6-methyl-3′-nitrobiphenyl-3-yl)-5-(trifluoromethyl)benzamide

ethanol

acetic acid

→

N-(3′-Amino-6-methylbiphenyl-3-yl)-3-fluoro-5-(trifluoromethyl)benzamide

المذيبات

EtOAc

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe mixture was then filtered
2. 2
   تركيزwas concentrated in vacuo
3. 3
   أخرىThe residue was used in the next reaction without purification

الإجراء التجريبي

To 3-fluoro-N-(6-methyl-3′-nitrobiphenyl-3-yl)-5-(trifluoromethyl)benzamide (4.09 g, 9.78 mmol) was added ethanol (93.2 mL) followed by iron (3.0 g, 54 mmol) and acetic acid (9.32 mL, 164 mmol). The solution was heated at 92° C. for 2 h using the rotovap motor/heating bath. To the reaction mixture was added EtOAc and the mixture was then filtered and was concentrated in vacuo. The residue was used in the next reaction without purification. MS (EI) m/z=389 (M+H).

المصدر