تفاعل #164865

معادلة التفاعل

Benzaldehyde

benzaldehyde

4-Acetylbenzonitrile

sodium hydroxide

water

→

yellow solid

المردود 91.0%

1-(4-Cyanophenyl)-3-phenyl-2-propen-1-one

المردود 91.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGthe mixture stirred for 2 hr at room temperature
2. 2
   ترشيحThe resulting mixture was filtered
3. 3
   أخرىrecrystallized from ethanol

الإجراء التجريبي

4-Acetylbenzonitrile (44al, 1.00 g, 6.9 mmol), sodium hydroxide (0.40 g, 10.0 mmol) and water (20 ml) were combined in ethanol (20 ml) and stirred for 15 min at room temperature. Benzaldehyde (1b, 0.70 ml, 6.9 mmol) was added and the mixture stirred for 2 hr at room temperature. The resulting mixture was filtered and recrystallized from ethanol to give 1.46 g (91%) of a yellow solid: mp 120° C. [expected mp 119-120° C.]; 1H NMR: δ 7.34 (m, 3H), 7.62 (m, 2H), 7.80 (m, 4H), 8.06 (d, 2H, J=8.1 Hz); 13C NMR: δ 115.9, 117.9, 121.1, 128.6, 128.8, 129.0, 131.0, 132.4, 134.3, 141.4, 146.4, 188.9.

المصدر