تفاعل #164731

معادلة التفاعل

6-iodo-1-(2-methoxyethyl)-2-(methylthio)pyrimidin-4(1H)-one

(2,5-dimethoxyphenyl)boronic acid

sodium carbonate

→

6-(2,5-dimethoxyphenyl)-1-(2-methoxyethyl)-2-(methylthio)pyrimidin-4(1H)-one

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   أخرىdegassed 1,4-dioxane (2 mL)
3. 3
   أخرىirradiation at 120° C. for 30 minutes
4. 4
   أخرىthe crude reaction mixture

الإجراء التجريبي

To a mixture of 6-iodo-1-(2-methoxyethyl)-2-(methylthio)pyrimidin-4(1H)-one (100 mg, 0.31 mmol), (2,5-dimethoxyphenyl)boronic acid (0.37 mmol, 1.2 equiv.) and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (14 mg, 0.017 mmol, 0.05 equiv) was added degassed 1,4-dioxane (2 mL), followed by a degassed solution of sodium carbonate (65 mg, 0.61 mmol) in water (0.7 mL). This reaction mixture was subjected to microwave irradiation at 120° C. for 30 minutes and the crude reaction mixture was used directly in the next step.

المصدر