تفاعل #164687

معادلة التفاعل

hydrochloric acid

methyl 3,5-diamino-6-chloropyrazine-2-carboxylate

methanol

NaOH

→

3,5-Diamino-6-chloropyrazine-2-carboxylic acid

المذيبات

Water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةis refluxed for 3 h
2. 2
   أخرىThe precipitate formed
3. 3
   ترشيحis collected by filtration
4. 4
   غسيلwashed with water
5. 5
   أخرىdried at 60° C

الإجراء التجريبي

A mixture of methyl 3,5-diamino-6-chloropyrazine-2-carboxylate (100 g; 494 mmol), methanol (1 L) and NaOH (6 mol/L in water; 240 mL; 1.44 mol) is refluxed for 3 h. The mixture is allowed to cool to room temperature and then neutralised by addition of hydrochloric acid (6 M in water; ca. 120 mL). Water (200 mL) is added. The precipitate formed is collected by filtration while applying suction, washed with water and dried at 60° C. Yield: 99.6 g (107% of theory).

المصدر