تفاعل #164679

معادلة التفاعل

Ethyl 4-chloroacetoacetate

2-methyl-2-propanethiol

triethylamine

→

desired product

4-tert-Butylsulfanyl-3-oxo-butyric acid ethyl ester

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONSilica gel was added
2. 2
   تركيزthe mixture was concentrated
3. 3
   ترشيحfiltered over a plug of silica gel

الإجراء التجريبي

Ethyl 4-chloroacetoacetate (7.5 mL, 51.9 mmol), 2-methyl-2-propanethiol (5.6 mL, 49.7 mmol), triethylamine (10.8 mL, 77.4 mmol), and catalytic tetrabutylammonium bromide were dissolved in THF (250 mL) and stirred at room temperature overnight. Silica gel was added, and the mixture was concentrated and filtered over a plug of silica gel to obtain the desired product (B-1), which was used without further purification.

المصدر