تفاعل #164610

معادلة التفاعل

4-(2,6-difluoro-4-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Intermediate II

4-(2,6-difluoro-4-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

→

title compound

المردود 95.0%

4-(4-Amino-2,6-difluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

المردود 95.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىFlask was evacuated
2. 2
   workup.ADDITIONhydrogen was introduced with the help of balloon
3. 3
   ترشيحOn completion, the reaction mixture was filtered through celite pad
4. 4
   أخرىThe filterate was evaporated

الإجراء التجريبي

To a solution of 4-(2,6-difluoro-4-nitro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (Intermediate II) (30 g, 0.09 mol), in methanol (500 mL) under argon atmosphere was added 10% Pd/C (4.5 g, 15 mol% by weight). Flask was evacuated and hydrogen was introduced with the help of balloon. The reaction mixture was stirred under hydrogen and progress of the reaction was monitored by TLC. On completion, the reaction mixture was filtered through celite pad using methanol as solvent. The filterate was evaporated to provide title compound (26 g, 95%) as pale yellow solid.

المصدر