تفاعل #164593

معادلة التفاعل

sodium cyanoborohydride

4-cyclopropylmethoxy-N—((S)-6-formyl-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methylbenzamide

THF

C-(tetrahydropyran-4-yl)methylamine

→

4-Cyclopropylmethoxy-N-methyl-N—((S)-6-{[(tetrahydropyran-4-ylmethyl)amino]methyl}-1,2,3,4-tetrahydronaphthalen-2-yl)benzamide

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe polymer was filtered off with suction
2. 2
   تركيزthe filtrate was concentrated
3. 3
   أخرىThe residue was purified by preparative HPLC
4. 4
   أخرىThe product was thus obtained with the monoisotopic molecular weight of 462.29 (C28H38N2O3)

الإجراء التجريبي

To a mixture of 4-cyclopropylmethoxy-N—((S)-6-formyl-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methylbenzamide (0.20 g), THF (5 ml), C-(tetrahydropyran-4-yl)methylamine (63 mg) and acetic acid (33 mg) was added polymer-bound sodium cyanoborohydride (0.55 mmol), and the suspension was shaken at room temperature for 12 hours. The polymer was filtered off with suction and the filtrate was concentrated. The residue was purified by preparative HPLC. The product was thus obtained with the monoisotopic molecular weight of 462.29 (C28H38N2O3); MS (ESI): 463.3 (M+H+).

المصدر