تفاعل #164518

معادلة التفاعل

2-hydroxymethyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane

compound 1

2-hydroxymethyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane

2-chloro-4-bromophenol

PTSA

→

product

المردود 95.0%

2-(4-bromo-2-chlorophenoxy)methyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane

المردود 95.0%

المذيبات

toluene

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىReaction mixture
2. 2
   درجة الحرارةwas refluxed
3. 3
   درجة الحرارةIt was then cooled
4. 4
   ترشيحfiltered
5. 5
   غسيلwash
6. 6
   أخرىToluene was removed under vacuum

الإجراء التجريبي

2-hydroxymethyl-8-phenethyl-1,4-dioxa-8-azaspiro[4,5]decane (compound 1, 50 gm, 0.18 mole) was dissolved in toluene (300 ml) at room temperature. To this 44 gms of 2-chloro-4-bromophenol in toluene (150 ml) was added at room temperature 28° C. in the presence of ParaToluenesulfonic Acid (PTSA, 3.5 gm). Reaction mixture was refluxed with stirring for 13 hrs. It was then cooled and filtered. The filtrate was given water wash to bring the pH to neutral. Toluene was removed under vacuum to obtain a thick brick red colored product 95% yield.

المصدر