تفاعل #164228

معادلة التفاعل

(R)-quinuclidin-3-yl 2-(4-fluorobenzylamino)-2-phenylacetate

2-bromo-1-phenylethanone

→

title compound

المردود 37.0%

(R)-3-[2-(4-fluoro-benzylamino)-2-phenyl-acetoxy]-1-(2-oxo-2-phenyl-ethyl)-1-azonia-bicyclo[2.2.2]octane bromide

المردود 37.0%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe solid is collected by suction filtration
2. 2
   غسيلwashed with Et2O
3. 3
   أخرىThe product is further purified by flash chromatography (DCM/MeOH=95/5 to 92/8)

الإجراء التجريبي

A mixture of (R)-quinuclidin-3-yl 2-(4-fluorobenzylamino)-2-phenylacetate (C78) (61 mg, 0.17 mmol) and 2-bromo-1-phenylethanone (33.0 mg, 0.17 mmol) in ethyl acetate (3 mL) is stirred at RT overnight. The solid is collected by suction filtration and washed with Et2O. The product is further purified by flash chromatography (DCM/MeOH=95/5 to 92/8) to obtain the title compound as a white solid (35 mg, 37% yield, bromide salt, mixture of diastereoisomers).

المصدر