تفاعل #164104

معادلة التفاعل

ether

ethyl-4-oxocyclohexane carboxylate

ethylene glycol

→

raw product

المردود 74.0%

1,4-dioxaspiro[4,5]decane-8-carboxylic acid ethyl ester

المردود 74.0%

المذيبات

toluol

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water and 5% sodium hydrogencarbonate solution (150 mL each)
2. 2
   تجفيفThe organic phase was dried with sodium sulphate
3. 3
   تركيزconcentrated to low volume in a vacuum

الإجراء التجريبي

A solution of ethyl-4-oxocyclohexane carboxylate (28.9 g, 169 mmol), ethylene glycol (36.7 g, 33.0 mL, 592 mmol) and p-toluol sulphonic acid (380 mg, 2.0 mmol) in toluol (90 mL) was stirred overnight at room temperature. The reaction solution was poured into ether (150 mL) and washed with water and 5% sodium hydrogencarbonate solution (150 mL each). The organic phase was dried with sodium sulphate and concentrated to low volume in a vacuum. Since the raw product (26.8 g) was obtained in pure form, it could be directly converted further.

المصدر