تفاعل #163486

ord-2cd5d913d41e441eb5cc445ddd0aa78f

معادلة التفاعل

II
iodine
CCCCCC=O
hexanal
CC(C)(N)C(F)(F)F
1,1,1-trifluoro-2-methylpropan-2-amine
CCOC(=O)N=C=S
O-ethyl carbonisothiocyanatidate
→
CCCCc1cn(C(C)(C)C(F)(F)F)s/c1=N\C(=O)OCC
title compound
CCCCc1cn(C(C)(C)C(F)(F)F)s/c1=N\C(=O)OCC
ethyl [(5Z)-4-butyl-2-(2,2,2-trifluoro-1,1-dimethylethyl)isothiazol-5(2H)-ylidene]carbamate

المتفاعلات

II
iodine
CCCCCC=O
hexanal
CC(C)(N)C(F)(F)F
1,1,1-trifluoro-2-methylpropan-2-amine
CCOC(=O)N=C=S
O-ethyl carbonisothiocyanatidate

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

Commercially available hexanal (Aldrich), 1,1,1-trifluoro-2-methylpropan-2-amine (Chemcollect), O-ethyl carbonisothiocyanatidate (Aldrich) and iodine were processed using the method described in Example 110A to afford the title compound. MS (ESI+) m/z 339 (M+H)+.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08835475B2uspto-grants-2014_09