تفاعل #163161

معادلة التفاعل

Sodium hydroxide

(R)-(+)-Methyl 3-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy]-5-[(1-methyl-2-oxo-pyrrolidin-3-yl) oxy]benzoate

Intermediate 19

(R)-(+)-Methyl 3-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy]-5-[(1-methyl-2-oxo-pyrrolidin-3-yl) oxy]benzoate

→

solid

المردود 71.5%

(R)-(+)-3-[4-(5-Methyl-1,3,4-oxadiazol-2-yl)phenoxy]-5-[(1-methyl-2-oxo-pyrrolidin-3-yl)oxy]benzoic acid

المردود 71.5%

المذيبات

MeOH H2O

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter completion, methanol was evaporated from the reaction mixture and water
2. 2
   workup.ADDITIONwas added
3. 3
   غسيلThe aqueous layer was washed with EtOAc
4. 4
   أخرىto obtain solid
5. 5
   أخرىThe solid obtained
6. 6
   ترشيحwas filtered
7. 7
   غسيلwashed with water
8. 8
   أخرىdried under suction or vacuum

الإجراء التجريبي

Sodium hydroxide (pallets, 0.35 g) was added To a stirring mixture of (R)-(+)-Methyl 3-[4-(5-methyl-1,3,4-oxadiazol-2-yl)phenoxy]-5-[(1-methyl-2-oxo-pyrrolidin-3-yl) oxy]benzoate (1.1 g) (Intermediate 19) in MeOH:H2O (1:1) at room temperature. The reaction was monitored by TLC. After completion, methanol was evaporated from the reaction mixture and water was added. The aqueous layer was washed with EtOAc, acidified with dil. HCl (0.05 N) to obtain solid. The solid obtained was filtered, washed with water, dried under suction or vacuum to get pure white solid (0.76 g).

المصدر