تفاعل #162888

معادلة التفاعل

Boc-Tle-OH

EDCI

DIPEA

benzyl alcohol

→

title compound

المردود 99.0%

(S)-benzyl 2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoic acid

المردود 99.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   غسيلThe mixture was washed several times with an aqueous solution of 5% citric acid
2. 2
   تجفيفThe organic layer was dried over sodium sulfate
3. 3
   ترشيحfiltered
4. 4
   workup.DISTILLATIONdistilled under reduced pressure

الإجراء التجريبي

Boc-Tle-OH (4.8 g, 22.3 mmol) was dissolved in dichloromethane (50 mL), and EDCI (4.3 g, 44.6 mmol), DMAP (0.6 g, 4.46 mmol), DIPEA (16 mL, 89.2 mmol), and benzyl alcohol (5 mL, 44.6 mmol) were added dropwise. The mixture was stirred at room temperature for 12 hours. The mixture was washed several times with an aqueous solution of 5% citric acid. The organic layer was dried over sodium sulfate, and filtered and distilled under reduced pressure to obtain the title compound as yellow oil (6.7 g, 99%).

المصدر