تفاعل #162876

ord-7a05c112722e49a2bf32401b4b571a5f

معادلة التفاعل

c1cc2[nH]ncc2cc1NC1C2CCC1NC2
Intermediate 23
c1cc2[nH]ncc2cc1NC1C2CCC1NC2
N-((1SR,4SR,7SR)-2-azabicyclo[2.2.1]heptan-7-yl)-1H-indazol-5-amine
Cc1ccc(C=O)cc1OCCO
3-(2-hydroxyethoxy)-4-methylbenzaldehyde
→
Cc1ccc(CN2CC3CCC2C3Nc2ccc3[nH]ncc3c2)cc1OCCO
title compound
Cc1ccc(CN2CC3CCC2C3Nc2ccc3[nH]ncc3c2)cc1OCCO
2-(5-(((1SR,4SR,7SR)-7-((1H-indazol-5-yl)amino)-2-azabicyclo[2.2.1]heptan-2-yl)methyl)-2-methylphenoxy)ethanol

المتفاعلات

c1cc2[nH]ncc2cc1NC1C2CCC1NC2
Intermediate 23
c1cc2[nH]ncc2cc1NC1C2CCC1NC2
N-((1SR,4SR,7SR)-2-azabicyclo[2.2.1]heptan-7-yl)-1H-indazol-5-amine
Cc1ccc(C=O)cc1OCCO
3-(2-hydroxyethoxy)-4-methylbenzaldehyde

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

Reaction of Intermediate 23 with 3-(2-hydroxyethoxy)-4-methylbenzaldehyde affords the title compound.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08835457B2uspto-grants-2014_09