تفاعل #162866

ord-8a8361b9bf57490f9f9053e36ae83a81

معادلة التفاعل

CCO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(Sc3nc(-c4cc[n+](C)cc4)cs3)CS[C@H]12)c1nsc(NP(=O)(O)O)n1
Ceftaroline fosamil
[NH-]C(=O)[C@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)O.[Na+]
trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium salt
C=C(C)C=CCCCCCl
chlorobutyl-isoprene
[Al]
Aluminum
N=C(N)NCCC[C@H](N)C(=O)O
L-Arginine
→
NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)[O-].[Na+]
NXL-104

المتفاعلات

CCO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(Sc3nc(-c4cc[n+](C)cc4)cs3)CS[C@H]12)c1nsc(NP(=O)(O)O)n1
Ceftaroline fosamil
[NH-]C(=O)[C@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)O.[Na+]
trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium salt
C=C(C)C=CCCCCCl
chlorobutyl-isoprene
[Al]
Aluminum
N=C(N)NCCC[C@H](N)C(=O)O
L-Arginine

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىsealed

الإجراء التجريبي

Ceftaroline fosamil, trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium salt (Form I) and L-Arginine were blended in a twin shell blender (Patterson-Kelly) for times ranging from 15 to 60 minutes. The blend was subsequently weighed into vials and the vials were stoppered (with or without nitrogen), sealed and stored at different conditions to monitor stability. Packaging components used were 20 ml Type I glass vial, Gray chlorobutyl-isoprene stopper and Blue Aluminum tear-off seal.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08835455B2uspto-grants-2014_09