تفاعل #1621694

معادلة التفاعل

4.4.7-trimethy-6-trimethylsilylethynylthiochroman

potassium hydroxide

→

title compound

4,4,7-Trimethyl-6-ethynylthiochroman

المذيبات

isopropanol

ظروف التفاعل

المعالجة

1. 1
   أخرىwas degassed under nitrogen
2. 2
   تركيزThe mixture was concentrated under vacuum
3. 3
   استخلاصextracted with 2×10 ml of ether
4. 4
   غسيلwashed successively with water and saturated NaCl solution
5. 5
   تجفيفdried (MgSO4)
6. 6
   أخرىThe solvent was removed in vacuo

الإجراء التجريبي

A mixture of 380 mg (1.69 mmol) of 4.4.7-trimethy-6-trimethylsilylethynylthiochroman, 4 ml of isopropanol and 2.5 ml of aqueous 1N potassium hydroxide was degassed under nitrogen and stirred at room temperature for 16 hours. The mixture was concentrated under vacuum and extracted with 2×10 ml of ether. The ether extracts were combined and washed successively with water and saturated NaCl solution and then dried (MgSO4). The solvent was removed in vacuo to give the title compound as a yellow oil.

المصدر