تفاعل #161750

معادلة التفاعل

sodium cyanoborohydride

6-fluoroindole

sodium hydroxide

→

6-fluoro-2,3-dihydro-1H-indole

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with EtOAc
2. 2
   غسيلThe combined organic phases were washed several times with saturated sodium hydrogen carbonate solution
3. 3
   أخرىdried on sodium sulphate
4. 4
   أخرىevaporated down

الإجراء التجريبي

Under a nitrogen atmosphere 0.29 g (4.6 mmol) sodium cyanoborohydride were added batchwise to 0.54 g (4.0 mmol) 6-fluoroindole in 5.0 mL glacial acetic acid and the mixture was stirred for 30 min. Then the reaction mixture was poured onto a 4N aqueous sodium hydroxide solution and extracted with EtOAc. The combined organic phases were washed several times with saturated sodium hydrogen carbonate solution, dried on sodium sulphate and evaporated down.

المصدر