تفاعل #161730

معادلة التفاعل

4,5-difluoroindoline hydrochloride

4-chloropicolinic acid

TBTU

→

(4-chloro-pyridin-2-yl)-(4,5-difluoro-2,3-dihydro-indol-1-yl)-methanone

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted successively with a 15% potassium carbonate solution, water
2. 2
   أخرىThe organic phase was dried
3. 3
   ترشيحfiltered
4. 4
   تركيزconcentrated to dryness by rotary evaporation
5. 5
   workup.STIRRINGThe residue was stirred with diisopropylether
6. 6
   ترشيحfiltered
7. 7
   أخرىdried

الإجراء التجريبي

0.50 g (3.2 mmol) 4-chloropicolinic acid, 1.1 g (3.4 mmol) TBTU and 0.91 mL (6.5 mmol) TEA were placed in 10 mL DMF. 0.63 g (3.3 mmol) 4,5-difluoroindoline hydrochloride were added. The reaction mixture was stirred overnight at RT and then extracted successively with a 15% potassium carbonate solution, water, a 1M HCl solution and EtOAc. The organic phase was dried, filtered and concentrated to dryness by rotary evaporation. The residue was stirred with diisopropylether and the undissolved solid was suction filtered and dried.

المصدر