تفاعل #1617223

معادلة التفاعل

Diisopropyl ether

2-methyl-1,3-thiazole

2-[(aminooxy)sulfonyl]-1,3,5-trimethylbenzene

→

title compound

المردود 63.0%

3-amino-2-methyl-1,3-thiazol-3-ium 2,4,6-trimethylbenzenesulfonate

المردود 63.0%

المذيبات

ethyl acetate toluene

toluene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooling
2. 2
   ترشيحthe resulting solid was collected by filtration

الإجراء التجريبي

To a solution of 2-methyl-1,3-thiazole (6.6 g, 67 mmol) in toluene (60 mL) was added a solution of 2-[(aminooxy)sulfonyl]-1,3,5-trimethylbenzene obtained in the above in ethyl acetate-toluene under ice-cooling, and the mixture was stirred for 2 hr. Diisopropyl ether (200 mL) was added to the reaction system, and the resulting solid was collected by filtration to give the title compound (13 g, 63%) as a white solid. The filtrate was concentrated under reduced pressure to about 100 mL, diisopropyl ether (100 mL) was added, and the resulting solid was collected by filtration to give the title compound (3.8 g, 18%) as a white solid (total yield 81%).

المصدر