تفاعل #1616425

معادلة التفاعل

DIPEA

4-[3-(6-Amino-pyridin-3-ylethynyl)-2-ethyl-pyridin-4-yl]-2-fluoro-benzoic acid

N-acetyl piperazine

HATU

→

title compound

1-(4-{4-[3-(6-Amino-pyridin-3-ylethynyl)-2-ethyl-pyridin-4-yl]-2-fluoro-benzoyl}-piperazin-1-yl)-ethanone

المذيبات

H2O ACN

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter completion of the reaction
2. 2
   ترشيحthe reaction mixture is filtered
3. 3
   أخرىthe product is isolated from the obtained solution by RP-HPLC

الإجراء التجريبي

The title compound is synthesized according to general procedure GP5 starting from 100 mg (0.28 mmol) 4-[3-(6-Amino-pyridin-3-ylethynyl)-2-ethyl-pyridin-4-yl]-2-fluoro-benzoic acid (A-38) using 46 mg (0.36 mmoL) N-acetyl piperazine, 116 mg (0.30 mmol) HATU and 81 μL DIPEA in 1 mL DMF. After completion of the reaction, the reaction mixture is filtered and the product is isolated from the obtained solution by RP-HPLC using a H2O/ACN-gradient. Yield: 69 mg (53%).

المصدر