تفاعل #1616424

معادلة التفاعل

DIPEA

4-[2-Ethyl-3-(6-methylamino-pyridin-3-ylethynyl)-pyridin-4-yl]-2-fluoro-benzoic acid

tetrahydro-pyran-4-yl piperazine

HATU

→

title compound

{4-[2-Ethyl-3-(6-methylamino-pyridin-3-ylethynyl)-pyridin-4-yl]-2-fluoro-phenyl}-[4-(tetrahydro-pyran-4-yl)-piperazin-1-yl]-methanone

المذيبات

H2O ACN

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter completion of the reaction
2. 2
   ترشيحthe reaction mixture is filtered
3. 3
   أخرىthe product is isolated from the obtained solution by RP-HPLC

الإجراء التجريبي

The title compound is synthesized according to general procedure GP5 starting from 100 mg (0.27 mmol) 4-[2-Ethyl-3-(6-methylamino-pyridin-3-ylethynyl)-pyridin-4-yl]-2-fluoro-benzoic acid (A-46) using 68 mg (0.40 mmoL) tetrahydro-pyran-4-yl piperazine, 101 mg (0.27 mmol) HATU and 50 μL DIPEA in 1.5 mL DMF. After completion of the reaction, the reaction mixture is filtered and the product is isolated from the obtained solution by RP-HPLC using a H2O/ACN-gradient. Yield: 59 mg (42%).

المصدر