تفاعل #1616417

معادلة التفاعل

DIPEA

4-[3-(6-Amino-pyridin-3-ylethynyl)-2-ethyl-pyridin-4-yl]-2-fluoro-benzoic acid

N-ethyl piperazine

HATU

→

title compound

{4-[3-(6-Amino-pyridin-3-ylethynyl)-2-ethyl-pyridin-4-yl]-2-fluoro-phenyl}-(4-ethyl-piperazin-1-yl)-methanone

المذيبات

H2O MeOH

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter completion of the reaction
2. 2
   ترشيحthe reaction mixture is filtered
3. 3
   أخرىthe product is isolated from the obtained solution by RP-HPLC

الإجراء التجريبي

The title compound is synthesized according to general procedure GP5 starting from 100 mg (0.28 mmol) 4-[3-(6-Amino-pyridin-3-ylethynyl)-2-ethyl-pyridin-4-yl]-2-fluoro-benzoic acid (A-38) using 38 mg (0.33 mmoL) N-ethyl piperazine, 116 mg (0.30 mmol) HATU and 81 μL DIPEA in 1 mL DMF. After completion of the reaction, the reaction mixture is filtered and the product is isolated from the obtained solution by RP-HPLC using a H2O/MeOH-gradient. Yield: 36 mg (28%).

المصدر