تفاعل #1615

معادلة التفاعل

3-benzyloxyphenol

potassium carbonate

(S)-Glycidyl-3-nitrobenzenesulphonate

→

title compound

(S)-Glycidyl-3-benzyloxyphenol

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةunder reflux for 15 mins
3. 3
   درجة الحرارةthe reaction mixture was heated
4. 4
   درجة الحرارةunder reflux for 23 hours
5. 5
   درجة الحرارةAfter cooling the reaction mixture
6. 6
   ترشيحwas filtered
7. 7
   أخرىthe solvent was evaporated
8. 8
   أخرىThe residue was partitioned between ethyl acetate and water
9. 9
   غسيلwashed with water and brine
10. 10
    أخرىdried
11. 11
    أخرىevaporated

الإجراء التجريبي

A mixture of 3-benzyloxyphenol (900 mg, 4.5 mMol) and potassium carbonate (1.87 g, 13.5 mMol) in acetone (45 ml) was heated under reflux for 15 mins. (S)-Glycidyl-3-nitrobenzenesulphonate (1.0 g, 4.5 mMol) was added and the reaction mixture was heated under reflux for 23 hours. After cooling the reaction mixture was filtered and the solvent was evaporated. The residue was partitioned between ethyl acetate and water. The organic fractions were combined, washed with water and brine, dried and evaporated to give the title compound as an oil.

المصدر