تفاعل #161132

معادلة التفاعل

4-tert-butyl-phenylamine

NBS

→

2-Bromo-4-tert-butyl-phenylamine

المذيبات

DMF

DMF

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصextracted with EtOAc
2. 2
   غسيلThe organic layer was washed with water, brine
3. 3
   تجفيفdried over Na2SO4
4. 4
   تركيزconcentrated
5. 5
   أخرىThe crude product was directly used in the next step without further purification

الإجراء التجريبي

To a solution of 4-tert-butyl-phenylamine (447 g, 3 mol) in DMF (500 mL) was added dropwise NBS (531 g, 3 mol) in DMF (500 mL) at room temperature. Upon completion, the reaction mixture was diluted with water and extracted with EtOAc. The organic layer was washed with water, brine, dried over Na2SO4 and concentrated. The crude product was directly used in the next step without further purification.

المصدر