تفاعل #161018

معادلة التفاعل

hydrochloric acid

1-[[[4-(4-propylpiperazin-1-yl)phenyl]carbonyl]amino]cyclohexanecarboxylic acid methyl ester

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title compound

المردود 41.0%

1-[[[4-(4-Propylpiperazin-1-yl)phenyl]carbonyl]amino]cyclohexanecarboxylic acid hydrochloride

المردود 41.0%

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was heated
2. 2
   درجة الحرارةunder reflux for 6 hours
3. 3
   ترشيحthe precipitated crystal was collected by filtration

الإجراء التجريبي

3 ml of 4N hydrochloric acid was added to 600 mg (1.55 mmol) of 1-[[[4-(4-propylpiperazin-1-yl)phenyl]carbonyl]amino]cyclohexanecarboxylic acid methyl ester, and the mixture was heated under reflux for 6 hours. The mixture was cooled to room temperature, and the precipitated crystal was collected by filtration to obtain 258 mg (41%) of the title compound.

المصدر