تفاعل #161012

معادلة التفاعل

2-oxo-1-imidazolidinecarbonyl chloride

1-aminocyclohexanecarboxylic acid phenylmethyl ester

triethylamine

→

title compound

المردود 82.2%

1-[[(2-Oxo-1-imidazolidinyl)carbonyl]amino]cyclohexanecarboxylic acid phenylmethyl ester

المردود 82.2%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   غسيلThe reaction solution was successively washed with water
2. 2
   تجفيفa 10% aqueous potassium hydrogensulfate solution, a saturated aqueous sodium hydrogencarbonate solution and saturated brine, and it was dried with anhydrous sodium sulfate
3. 3
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure
4. 4
   غسيلthe obtained crystal was washed with diethyl ether

الإجراء التجريبي

1.38 g (9.3 mmol) of 2-oxo-1-imidazolidinecarbonyl chloride was added to a solution of 2.17 g (9.3 mmol) of 1-aminocyclohexanecarboxylic acid phenylmethyl ester and 1.04 g (10 mmol) of triethylamine in 100 ml of chloroform, and the mixture was stirred at 60° C. for 4 days. The reaction solution was successively washed with water, a 10% aqueous potassium hydrogensulfate solution, a saturated aqueous sodium hydrogencarbonate solution and saturated brine, and it was dried with anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the obtained crystal was washed with diethyl ether to obtain 2.64 g (82%) of the title compound.

المصدر