تفاعل #160984

معادلة التفاعل

aniline

1-chloro-1,1,2,2-tetrafluoro-2-iodoethane

NaHCO3

→

title compound

4-(2-Chloro-1,1,2,2-tetrafluoroethyl)aniline

المذيبات

DMF

Et2O

ظروف التفاعل

المعالجة

1. 1
   أخرىThe vial was sealed
2. 2
   درجة الحرارةAfter cooling at RT
3. 3
   غسيلwashed with NaHCO3 10% and brine
4. 4
   تجفيفdried over MgSO4
5. 5
   أخرىthe solvent was evaporated off
6. 6
   أخرىto give a residue which
7. 7
   أخرىwas purified by flash chromatography (RediSep® Silica gel column, n-heptane/EtOAc, from 0 to 25% EtOAc) and further by reverse phase chromatography (MPLC, Lichroprep® 15-25 μm column, eluents: water+0.1% formic/MeCN+0.1% formic acid, gradient 10 to 50% MeCN+0.1% formic acid)
8. 8
   workup.ADDITIONThe fractions containing pure product
9. 9
   أخرىthe MeCN was evaporated off under reduced pressure
10. 10
    أخرىto give an aq. phase which
11. 11
    استخلاصextracted with Et2O
12. 12
    تجفيفThe combined extracts were dried over MgSO4
13. 13
    أخرىthe solvent was evaporated off under reduced pressure

الإجراء التجريبي

Ni(PPh3)4 (222 mg, 0.2 mmol) was added to a mixture of aniline (745 mg, 8 mmol) and 1-chloro-1,1,2,2-tetrafluoro-2-iodoethane (1049 mg, 4 mmol) in DMF (10 mL) in a MW vial under an argon atmosphere. The vial was sealed and the RM was stirred for two days at 80° C. After cooling at RT, the RM was dissolved in Et2O, washed with NaHCO3 10% and brine, dried over MgSO4 and the solvent was evaporated off under reduce pressure to give a residue which was purified by flash chromatography (RediSep® Silica gel column, n-heptane/EtOAc, from 0 to 25% EtOAc) and further by reverse phase chromatography (MPLC, Lichroprep® 15-25 μm column, eluents: water+0.1% formic/MeCN+0.1% formic acid, gradient 10 to 50% MeCN+0.1% formic acid). The fractions containing pure product were combined and the MeCN was evaporated off under reduced pressure to give an aq. phase which was neutralized with NaHCO3 and extracted with Et2O. The combined extracts were dried over MgSO4 and the solvent was evaporated off under reduced pressure to afford the title compound as a red oil. HPLC (Condition 4) tR=5.48 min, UPLC-MS (Condition 3) tR=1.04 min, m/z=269 [M+H]+.

المصدر