تفاعل #160625

معادلة التفاعل

2-(3-Hydroxy-4-methoxyphenyl)acetic acid

p-Toluenesulfonic acid monohydrate

→

title compound

Ethyl 2-(3-hydroxy-4-methoxyphenyl)acetate

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىis consumed
2. 2
   تركيزThe reaction mixture was concentrated
3. 3
   workup.ADDITIONdiluted with ethyl acetate
4. 4
   غسيلwashed with 1M HCl
5. 5
   تجفيفThe organic layer was dried over Na2SO4
6. 6
   ترشيحfiltered
7. 7
   تركيزconcentrated
8. 8
   أخرىpurified by flash chromatography on a silica gel column (hex:ethyl acetate 2:1)

الإجراء التجريبي

The stirred solution of 2-(3-Hydroxy-4-methoxyphenyl)acetic acid (9.82 g, 53.90 mmol) and p-Toluenesulfonic acid monohydrate (1.15 g, 6.0 mmol) in abs ethanol (100 ml) was refluxed for 4 hours or until all the starting material is consumed. The reaction mixture was concentrated, diluted with ethyl acetate and washed with 1M HCl. The organic layer was dried over Na2SO4, filtered, concentrated, and purified by flash chromatography on a silica gel column (hex:ethyl acetate 2:1) to give the title compound.

المصدر