تفاعل #1605848

معادلة التفاعل

chloromethyl chloroformate

NaH

aripiprazole

NaH

→

chloromethyl 7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-oxo-3,4-dihydroquinoline-1(2H)-carboxylate

المذيبات

ethyl acetate

2-methyltetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthen heated
2. 2
   درجة الحرارةto reflux for 3 hours
3. 3
   درجة الحرارةThe reaction was cooled to room temperature
4. 4
   workup.STIRRINGthe reaction stirred for 2 hours
5. 5
   درجة الحرارةThe reaction was cooled to 0° C.
6. 6
   أخرىquenched with aqueous saturated NaHCO3 solution (20 mL)
7. 7
   استخلاصThe reaction was extracted with ethyl acetate (3×20 mL)
8. 8
   غسيلthe combined organics washed with brine (50 mL)
9. 9
   تجفيفdried (MgSO4)
10. 10
    تركيزconcentrated

الإجراء التجريبي

To a suspension of aripiprazole (1 g, 2.23 mmol) in 2-methyltetrahydrofuran (20 mL) was added NaH (178 mg, 4.46 mmol). After 1 hour, a further of NaH (178 mg) was added. The reaction was stirred at ambient temperature overnight then heated to reflux for 3 hours. The reaction was cooled to room temperature and chloromethyl chloroformate (0.60 mL, 6.69 mmol) was then added and the reaction stirred for 2 hours. The reaction was cooled to 0° C., diluted with ethyl acetate (20 mL) and quenched with aqueous saturated NaHCO3 solution (20 mL). The reaction was extracted with ethyl acetate (3×20 mL) and the combined organics washed with brine (50 mL), then dried (MgSO4) and concentrated to give chloromethyl 7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-2-oxo-3,4-dihydroquinoline-1(2H)-carboxylate (crude yield 1.54 g) as a 2:1 mixture of product/aripiprazole. The product was taken onto the next step crude.

المصدر