تفاعل #1605844

معادلة التفاعل

pivaloyl chloride

dehydro-aripiprazole

pyridine

→

7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2-yl pivalate

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water
2. 2
   تجفيفdried over MgSO4
3. 3
   أخرىAfter evaporation the residue
4. 4
   أخرىfurther purified on silica eluting with ethyl acetate
5. 5
   أخرىAfter evaporation of the product
6. 6
   workup.ADDITIONcontaining fraction
7. 7
   أخرىCompound-316 (0.53 g) was obtained as a colourless oil

الإجراء التجريبي

To a solution of dehydro-aripiprazole (1.2 g, 2.7 mmol) in dichloromethane (30 mL) was added pyridine (1 mL), followed by pivaloyl chloride (0.66 mL, 5.4 mmol). The reaction mixture was stirred for 20 hours, then washed with water and dried over MgSO4. After evaporation the residue was co-evaporated with toluene and then further purified on silica eluting with ethyl acetate. After evaporation of the product containing fraction, Compound-316 (0.53 g) was obtained as a colourless oil.

المصدر