تفاعل #1605841

معادلة التفاعل

dibenzylcarbamoyl chloride

dehydro-aripiprazole

→

7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2-yl dibenzylcarbamate

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe reaction mixture heated
2. 2
   درجة الحرارةat reflux for 4 h
3. 3
   تركيزThe reaction mixture was concentrated
4. 4
   workup.DISSOLUTIONThe residue was dissolved in ethyl acetate (ethyl acetate)
5. 5
   غسيلwashed with water
6. 6
   تجفيفdried over MgSO4
7. 7
   أخرىAfter evaporation the residue
8. 8
   أخرىwas further purified on silica eluting with ethyl acetate
9. 9
   أخرىafter drying
10. 10
    أخرىgave Compound-342 (0.71 g) as a white solid

الإجراء التجريبي

To a solution of dibenzylcarbamoyl chloride (1.7 g, 6.7 mmol) in pyridine (15 mL) was added dehydro-aripiprazole (1.5 g, 3.4 mmol) and the reaction mixture heated at reflux for 4 h. The reaction mixture was concentrated and the residue co-evaporated with toluene (×3). The residue was dissolved in ethyl acetate (ethyl acetate), washed with water and dried over MgSO4. After evaporation the residue was further purified on silica eluting with ethyl acetate and after drying gave Compound-342 (0.71 g) as a white solid.

المصدر