تفاعل #1605835

معادلة التفاعل

aripiprazole

dibenzylcarbamoyl chloride

2-methyltetrahydrofuran

→

7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-3,4-dihydroquinolin-2-yl dibenzylcarbamate

المذيبات

ethyl acetate

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةat reflux for 4 days
3. 3
   درجة الحرارةThe reaction mixture was cooled
4. 4
   ترشيحfiltered through celite
5. 5
   أخرىThe organic phase was separated
6. 6
   تجفيفdried over MgSO4
7. 7
   أخرىevaporated
8. 8
   أخرىThe residue obtained
9. 9
   أخرىwas further purified on silica eluting with ethyl acetate/tetrahydrofuran
10. 10
    أخرىto give
11. 11
    أخرىafter evaporation of the major product
12. 12
    workup.ADDITIONcontaining fractions, Compound-80 (1.02 g)

الإجراء التجريبي

A mixture of aripiprazole (1.5 g, 3.3 mmol), dibenzylcarbamoyl chloride (1.74 g, 6.7 mmol) silver carbonate (3.75 g, 13.4 mmol) and 2-methyltetrahydrofuran (30 mL) was heated at reflux for 4 days. The reaction mixture was cooled, diluted with ethyl acetate and water, and then filtered through celite. The organic phase was separated, dried over MgSO4 and evaporated. The residue obtained was further purified on silica eluting with ethyl acetate/tetrahydrofuran to give after evaporation of the major product containing fractions, Compound-80 (1.02 g) was a yellow oil.

المصدر