تفاعل #1605824

معادلة التفاعل

sodium ethoxide

1-(chloromethyl)-4-nitrobenzene

2-nitropropane

→

1-(2-methyl-2-nitropropyl)-4-nitrobenzene

المردود 76.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was heated
2. 2
   درجة الحرارةunder reflux for 18 hours
3. 3
   ترشيحThe reaction solution was filtered
4. 4
   تركيزconcentrated under reduced pressure
5. 5
   workup.ADDITIONdiluted with ethyl acetate
6. 6
   غسيلThe organic layer was washed with a saturated aqueous solution of sodium chloride
7. 7
   تجفيفdried over anhydrous magnesium sulfate
8. 8
   تركيزconcentrated under reduced pressure
9. 9
   أخرىThe residue was purified by flash column chromatography

الإجراء التجريبي

To a solution of sodium ethoxide (3.5 g, 50 mmol) in ethanol (100 mL), 1-(chloromethyl)-4-nitrobenzene (8.6 g, 50 mmol) and 2-nitropropane (2.2 g, 250 mmol) were added at room temperature, and the mixture was heated under reflux for 18 hours. The reaction solution was filtered, concentrated under reduced pressure, and diluted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by flash column chromatography to obtain 1-(2-methyl-2-nitropropyl)-4-nitrobenzene (8.52 g).

المصدر