تفاعل #1605816

معادلة التفاعل

boron tribromide

4-Methoxy-2-nitro-1-phenylbenzene

→

3-nitro-4-phenylphenol

المذيبات

dichloromethane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added, under ice-water cooling
2. 2
   workup.ADDITIONthe reaction mixture was poured onto ice
3. 3
   أخرىthe reaction
4. 4
   استخلاصextracted with ethyl acetate
5. 5
   غسيلThe organic layer was washed with a saturated aqueous solution of sodium chloride
6. 6
   تجفيفdried over anhydrous magnesium sulfate
7. 7
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

4-Methoxy-2-nitro-1-phenylbenzene (1.86 g, 8.31 mmol) was dissolved in dichloromethane (40 mL) and thereto was added, under ice-water cooling, a solution of boron tribromide (2 mL) in dichloromethane (10 mL) After stirring at room temperature for 18 hours, the reaction mixture was poured onto ice to stop the reaction and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to obtain 3-nitro-4-phenylphenol as a crude material.

المصدر