تفاعل #1605812

معادلة التفاعل

2-Phenyl-N-acetylaniline

hydrogen bromide

→

2-phenyl-4-bromo-N-acetylaniline

المردود 91.3%

المذيبات

carbon tetrachloride

acetic acid

ظروف التفاعل

المعالجة

1. 1
   تركيزThe solution was concentrated under reduced pressure, to the residue
2. 2
   workup.ADDITIONwas added water (20 mL) and subsequently ethanol (30 mL)
3. 3
   workup.STIRRINGthe mixture was stirred under ice bath for 1 hour
4. 4
   ترشيحThe precipitate was collected by filtration
5. 5
   غسيلwashed with ethanol/water (=1:1)
6. 6
   أخرىdried under reduced pressure

الإجراء التجريبي

2-Phenyl-N-acetylaniline (6.21 g, 29.40 mmol) was dissolved in acetic acid (70 mL). Thereto was dropwise added under ice bath a separately prepared solution of hydrogen bromide (6.14 g, 38.42 mmol) dissolved in carbon tetrachloride (19.21 mL) and the mixture was stirred at room temperature overnight. The solution was concentrated under reduced pressure, to the residue was added water (20 mL) and subsequently ethanol (30 mL), and the mixture was stirred under ice bath for 1 hour. The precipitate was collected by filtration, washed with ethanol/water (=1:1), dried under reduced pressure to obtain 2-phenyl-4-bromo-N-acetylaniline (7.79 g).

المصدر