تفاعل #1605805

معادلة التفاعل

4-(3-Amino-4-phenylphenyl)butyric acid

tosylic acid hydrate

water

→

benzyl 4-(3-amino-4-phenylphenyl)butyrate tosylate

المردود 171.2%

المذيبات

toluene

benzyl alcohol

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwere added
2. 2
   درجة الحرارةthe mixture was heated
3. 3
   أخرىremoved by a Dean-Stark trap
4. 4
   تركيزThe reaction solution was concentrated under reduced pressure
5. 5
   أخرىa solid obtained
6. 6
   غسيلwas washed with a mixed solvent of hexane-ethyl acetate (4:1)
7. 7
   ترشيحThe solid was collected by filtration
8. 8
   أخرىdried under reduced pressure

الإجراء التجريبي

To a suspension of 4-(3-Amino-4-phenylphenyl)butyric acid (21.6 g, 84.6 mmol) in toluene (300 mL), benzyl alcohol (50 mL) and tosylic acid hydrate (17.7 g, 93.0 mmol) were added, and the mixture was heated under reflux for 5 hours with water removed by a Dean-Stark trap. The reaction solution was concentrated under reduced pressure and a solid obtained was washed with a mixed solvent of hexane-ethyl acetate (4:1). The solid was collected by filtration and dried under reduced pressure to obtain benzyl 4-(3-amino-4-phenylphenyl)butyrate tosylate (41.2 g).

المصدر